Why Is It Harder To Generate A Second Action Potential

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Why Is It Harder To Generate A Second Action Potential?

4. Why is it harder to generate a second action potential during the relative refractory period? A greater stimulus is required because voltage gated potassium channels that oppose depolarization are open during this time.4. Why is it harder to generate a second action potential during the relative refractory period

refractory period
In physiology a refractory period is a period of time during which an organ or cell is incapable of repeating a particular action or (more precisely) the amount of time it takes for an excitable membrane to be ready for a second stimulus once it returns to its resting state following an excitation.

Why are multiple action potentials generated in response to a long stimulus that is above threshold?

Why are multiple action potentials generated in response to a long stimulus that is above threshold? The longer stimuli allow time for recovery and the above threshold allows the action potential to occur after the relative refractory period.

Which of the following best explains why it is more difficult to trigger another action potential during the relative refractory period?

Which of the following best explains why it is more difficult to trigger another action potential during the relative refractory period? Voltage-gated K+ channels are open causing the inside of the cell to become more negative relative to the outside of the cell which opposes depolarization.

Why can a second action potential occur in the relative refractory period?

The cell membrane cannot immediately produce a second AP. … As voltage-gated Na+ channels transition from the inactivated to the closed state (i.e. they become capable of being activated) the membrane becomes capable of supporting a 2nd action potential – this period is called the RELATIVE REFRACTORY PERIOD.

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How many action potentials could be stimulated per second?

Physiologically action potential frequencies of up to 200-300 per second (Hz) are routinely observed.

Does stimulus intensity affect action potential?

When the intensity of the stimulus is increased the size of the action potential does not become larger. Rather the frequency or the number of action potentials increases.

How did the threshold for the second action potential change as you further decreased?

How did the threshold for the second action potential change as you further decreased the interval between the stimuli? The threshold for the second action potential will be higher which indeed requires increased strength in the stimulus.

Why is it harder to fire a second action potential in the relative refractory period?

4. Why is it harder to generate a second action potential during the relative refractory period? A greater stimulus is required because voltage-gated potassium channels that oppose depolarization are open during this time.

Why an action potential Cannot be initiated during the absolute refractory period?

During the absolute refractory period another action potential will not start. This is because of the inactivation gate of the voltage-gated Na+ channel.

Why can an action potential be generated during the absolute refractory period?

During the absolute refractory period a second stimulus (no matter how strong) will not excite the neuron. … After the absolute refractory period Na+ channels begin to recover from inactivation and if strong enough stimuli are given to the neuron it may respond again by generating action potentials.

Does hyperpolarization cause action potential?

Hyperpolarization is a change in a cell’s membrane potential that makes it more negative. It is the opposite of a depolarization. It inhibits action potentials by increasing the stimulus required to move the membrane potential to the action potential threshold.

Why is the refractory period important?

The refractory period limits the rate at which action potentials can be generated which is an important aspect of neuronal signaling. Additionally the refractory period facilitates unidirectional propagation of the action potential along the axon.

How would the absolute refractory period be affected?

How would the absolute refractory period be affected if voltage-gated sodium channels remained inactivated? It would be longer than normal. … The membrane channels upstream are refractory and cannot open.

Why does an action potential not get smaller as it propagates?

An action potential does not get smaller as it propagates along an axon. … Conduction of action potentials is faster in myelinated axons because myelin allows the axon membrane between myelin sheath gaps to change its voltage rapidly and allows current to flow only at the widely spaced gaps.

What does a stronger stimulus to a neuron results in?

Stronger stimuli increase the voltage of graded potentials. However action potentials are “all or nothing” so they all have the same voltage. In contrast stronger stimuli increase the frequency of action potentials.

What characterizes repolarization the second phase of the action potential?

What characterizes repolarization the second phase of action potential? Once the membrane depolarizes to a peak value of +30 mV it repolarizes to its negative resting value of -70mV.

How does a stimulus cause an action potential?

Action potentials are caused when different ions cross the neuron membrane. A stimulus first causes sodium channels to open. Because there are many more sodium ions on the outside and the inside of the neuron is negative relative to the outside sodium ions rush into the neuron.

What effect will the increased stimulus intensity?

4. Predict Question: What effect will the increased stimulus intensity have on the frequency of action potentials? Your answer: The frequency of action potentials will increase.

Why doesn’t action potential amplitude increase when stimulus increases?

After an action potential is stimulated the period of time the neuron needs to recover. … As stimulus intensity is increased the action potential amplitude remains the same (all-or-none events) but frequency at which the neuron responds to the stimulus increases.

What happened to the ability to produce a second AP when you decreased the interval between stimuli?

The threshold for the second action potential will be higher (requiring a larger depolarization). … A 20 mV depolarization to -50 mV. As the interval between stimuli decreases the depolarization needed to generate the second action potential. increases.

Why does the threshold increase when the interval between?

Why does the threshold increase when the interval between the stimuli decreases? Some sodium channels have been inactivated and cannot be reopened immediately. … a greater-than-threshold depolarization results and sodium permeability into the cell increases to overcome the potassium exiting.

Why does a nerve’s action potential increase slightly when you add 1.0 V to the threshold voltage and stimulate the nerve?

Why does a nerve’s AP increase slightly when you add 1.0 V to the threshold voltage and stimulate the nerve? The greater the voltage the more APs are generated. Increasing voltage results in depolarization of increasing numbers of neurons in a nerve.

What is the effect of myelination on conduction velocity and why?

By acting as an electrical insulator myelin greatly speeds up action potential conduction (Figure 3.14). For example whereas unmyelinated axon conduction velocities range from about 0.5 to 10 m/s myelinated axons can conduct at velocities up to 150 m/s.

Why is there no response at R3?

Why is there no response at R3 when you apply a very weak stimulus to the sensory receptor? … The very weak stimulus does not depolarize the axon of the sensory neuron to threshold.

Why are fewer action potentials recorded at R2 when lidocaine is applied between R1 and R2 How well did the results compare with your prediction?

If a nerve rather than an axon had been used in the lidocaine experiment the responses recorded at R1 and R2 would be the sum of all the action potentials (called a compound action potential). … Fewer action potentials were recorded at R2 because the voltage gated sodium channel is blocked.

During which period can a second action potential be initiated by a larger than normal stimulus?

The relative refractory period is a period after one action potential is initiated when it is possible to initiate a second action potential but only with a greater depolarization than was necessary to initiate the first.

Why does the action potential only move away from the cell body?

An efflux of potassium from the current action potential depolarizes the adjacent area. … Why does the action potential only move away from the cell body? The flow of the sodium ions only goes in one direction—away from the cell body. The areas that have had the action potential are refractory to a new action potential.

Which of the following would have the slowest action potential conduction velocity?

Action Potential: Conducting Velocity
Question Answer
Action potential conduction velocity is fastest in which of the following fibers? A fibers (large diameter heavily myelinated)
Action potential conduction velocity is slowest in which of the following fibers? C fibers

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Is it possible for a second action potential to occur during the relative refractory period explain your answer?

The cell membrane cannot immediately produce a second AP. The period of time when the majority of voltage-gated Na+ channels are inactivated defines the ABSOLUTE REFRACTORY PERIOD when no amount of depolarizing current can cause an action potential.

Why are multiple action potentials generated in response to a long stimulus that is above threshold?

Why are multiple action potentials generated in response to a long stimulus that is above threshold? The longer stimuli allow time for recovery and the above threshold allows the action potential to occur after the relative refractory period.

Does the absolute refractory period prevents summation of action potentials?

The refractory period prevents the action potential from travelling backwards. … The absolute refractory period is when the membrane cannot generate another action potential no matter how large the stimulus is. This is because the voltage-gated sodium ion channels are inactivated.

Why doesn’t This second pulse cause a second spike phrase your answer in terms of gates and voltages?

Phrase your answer in terms of gates and voltages. Answer 2. The second pulse takes place during refractory period when action potential cannot be generated. … This means that Na gates cannot open (depolarize membrane potential).

Why does hyperpolarization occur during an action potential?

Depolarization and hyperpolarization occur when ion channels in the membrane open or close altering the ability of particular types of ions to enter or exit the cell. … The opening of channels that let positive ions flow out of the cell (or negative ions flow in) can cause hyperpolarization.

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What is the cause of hyperpolarization after an action potential?

Hyperpolarization occurs due to an excess of open potassium channels and potassium efflux from the cell.

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